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desvenlafaxine will enhance the level or outcome of codeine by affecting hepatic enzyme CYP2D6 metabolism. Use Warning/Monitor. Desvenlafaxine inhibits CYP2D6; with better desvenlafaxine doses (ie, 400 mg) reduce the CYP2D6 substrate dose by as many as 50%; no dosage adjustment desired with desvenlafaxine doses 7 consecutive days straight away just